Chromosome 6 by Robin Cook. Chapter 1, 2, 3, 4

sequencer and the five-hundred-thousand-dollar globular NMR machine that

sprouted a tangle of wires like a giant sea anemone. He glanced at the

PCR’s, whose red lights blinked like distant quasars announcing

successive DNA-strand doublings. It was an environment that had

previously filled Kevin with hope and promise. But now each Eppendorf

microcentrifuge tube and each tissue-culture flask stood as mute

reminders of the building foreboding he was experiencing.

Advancing to his desk, Kevin looked down at his gene map of the short

arm of chromosome 6. His area of principal interest was outlined in red.

It was the major histocompatibility complex. The problem was that the

MHC was only a small portion of the short arm of chromosome 6. There

were large blank areas that represented millions and millions of base

pairs, and hence hundreds of other genes. Kevin did not know what they

did.

A recent request for information concerning these genes that he’d put

out over the Internet had resulted in some vague replies. Several

researchers had responded that the short arm of chromosome 6 contained

genes that were involved with muscular-skeletal development. But that

was it. There were no details.

Kevin shuddered involuntarily. He raised his eyes to the large picture

window above his desk. As usual it was streaked with moisture from the

tropical rain that swept across the view in undulating sheets. The

droplets slowly descended until enough had fused to reach a critical

mass. Then they raced off the surface like sparks from a grinding wheel.

Kevin’s eyes focused into the distance. The contrast between the

gleaming, air-conditioned interior with the outside world was always a

shock. Roiling, gun-metal gray clouds filled the sky despite the fact

that the dry season was supposed to have begun three weeks previously.

The land was dominated by riotous vegetation that was so dark green as

to almost appear black. Along the edge of the town it rose up like a

gigantic, threatening tidal wave.

Kevin’s office was in the hospital-laboratory complex that was one of

the few new structures in the previously decaying and deserted Spanish

colonial town of Cogo in the little-known African country of Equatorial

Guinea. The building was three stories tall. Kevin’s office was on the

top floor, facing southeast. From his window he could see a good portion

of the town as it sprawled haphazardly toward the Estuario del Muni and

its contributory rivers.

Some of the neighboring buildings had been renovated, some were in the

process, but most had not been touched. A half dozen previously handsome

haciendas were enveloped by vines and roots of vegetation that had gone

wild. Over the whole scene hung the perennial mist of super-saturated

warm air.

In the immediate foreground Kevin could see beneath the arched arcade of

the old town hall. In the shadows were the inevitable handful of

Equatoguinean soldiers in combat fatigues with AK-47’s haphazardly slung

over their shoulders. As usual they were smoking, arguing, and consuming

Cameroonean beer.

Finally Kevin let his eyes wander beyond the town. He’d been

unconsciously avoiding doing so, but now he focused on the estuary whose

rain-lashed surface looked like beaten tin. Directly south he could just

make out the forested shoreline of Gabon. Looking to the east he

followed the trail of islands that stretched toward the interior of the

continent. On the horizon he could see the largest of the islands, Isla

Francesca, named by the Portuguese in the fifteenth century. In contrast

to the other islands, Isla Francesca had a jungle-covered limestone

escarpment that ran down its center like the backbone of a dinosaur.

Kevin’s heart skipped a beat. Despite the rain and the mist, he could

see what he’d feared he’d see. Just like a week ago there was the

unmistakable wisp of smoke lazily undulating toward the leaden sky.

Kevin slumped into his desk chair and cradled his head in his hands. He

asked himself what he’d done. Having minored in the Classics as an

undergraduate, he knew about Greek myths. Now he questioned if he’d made

a Promethean mistake. Smoke meant fire, and he had to wonder if it was

the proverbial fire inadvertently stolen from the gods.

6:45 P.M.

BOSTON, MASSACHUSETTS

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