Acceptable Risk by Robin Cook

After a lengthy, rational discussion, they came up with a theory of what was happening. They reasoned that when the concentration of Ultra got to a certain point, it progressively blocked the normal variation of serotonin levels that occurred during sleep, ironing them out and altering sleep patterns.

It was Gloria who suggested that when the concentration got even higher, perhaps to the point where the sharp upward swing of the curve occurred, then the Ultra blocked the radiations from the lower, or reptilian, brain to the higher centers in the cerebral hemispheres. Sleep, like other autonomous function, was regulated by the lower brain areas where the Ultra was massing.

The group was quiet for a time while everyone pondered this hypothesis. Despite their emotional recovery, they all found this idea disturbing.

“If this were the case,” David said, “what would happen if we were to wake up while this blockage was in place?”

“It would be as if we’d experienced retroevolution,” Curt said. “We’d be functioning on our lower-brain centers alone. We’d be like carnivorous reptiles!”

The shock of this statement quieted everyone with its horrid connotations.

“Wait a minute, everybody,” Edward said, trying to cheer himself as well as the others. “We’re jumping to conclusions that are not based on fact. This is all complete supposition. We have to remember that we’ve seen no problems with the monkeys, who we all agree have cerebral hemispheres, although smaller than humans’, at least most humans.”

Everyone except Gloria smiled at Edward’s humor.

“Even if there is a problem with Ultra,” Edward reminded them, “we have to take into consideration the good side of the drug, and how it has positively affected our emotions, mental abilities, acuity of our senses, and even long-term memory. Perhaps we have been taking too much of the drug and we should cut down. Maybe we should cut down to Eleanor’s level since all she’s experienced are the positive psychological effects.”

“I’m not cutting back,” Gloria said defiantly. “I’m stopping as of this minute. It horrifies me to think of the possibility of some primitive creature lurking inside my body without my even being aware and sneaking out to forage in the night.”

“Very colorfully said,” Edward remarked. “You are welcome to stop the drug. That goes without saying. No one is going to force anyone to do anything they don’t want to do. You all know that. Each person can decide whether to continue taking the drug or not, and here’s what I suggest: for an added cushion of safety I think we should halve Eleanor’s dose and use that as an upper limit, dropping subsequent doses in one-hundred-milligram steps.”

“That sounds reasonable and safe to me,” David said.

“To me as well,” Curt said.

“And me,” François said.

“Good,” Edward said. “I’m absolutely confident that if the problem is as we’ve theorized, it has to be dose related, and there has to be a point where the chances of causing the problem is an acceptable risk.”

“I’m not taking it,” Gloria restated.

“No problem,” Edward said.

“You won’t be irritated with me?” Gloria asked.

“Not in the slightest,” Edward said.

“I’ll be able to be a control,” Gloria said. “Plus I’ll be able to watch over the others at night.”

“Excellent idea,” Edward said.

“I have a suggestion,” François said. “Perhaps we should all take radioactively tagged Ultra so I can follow the buildup and chart concentrations in our brains. The ultimate dose of Ultra might be that dose which merely maintains a specific level of Ultra without continually increasing it.”

“I’d agree to that idea,” Curt said.

“One other thing,” Edward said. “I’m sure I don’t have to remind all you professionals, but this meeting must be kept secret from everyone, including your families.”

“That goes without saying,” David said. “The last thing any of us wants to do is compromise Ultra’s future. We might have a little growing pains here and there, but it’s still going to be the drug of the century.”

Kim had intended to spend some time in the castle during the morning, but when she got back to the cottage she realized it was already lunchtime. While she was eating, the phone rang. To her surprise it was Katherine Sturburg, the archivist at Harvard who had a particular interest in Increase Mather.

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