Acceptable Risk by Robin Cook

“Pretty good considering what we have to deal with,” Edward said. “Our biggest problem is that we’re still experiencing ‘fits’ even though the Ultra has completely been cleared from our brains.”

“Are they still brought on by sleep?” Kim asked.

“Not by sleep,” Edward said. “They now come on spontaneously like an epileptic seizure, without any warning. The good part is that they only last for a half hour or less, even when untreated.”

“I’m so sorry,” Kim said. She struggled against a sadness that threatened to well up inside of her. She was facing people whose lives had been all but destroyed.

“We’re the sorry ones,” Edward said.

“It’s our own fault,” Gloria said. “We should have known better than to start taking the drug until all the toxicity studies were completed.”

“I don’t see that would have made any difference,” Edward said. “To this day, no animal studies have shown this human side effect. In fact, by our taking the drug when we did, we probably saved a large number of human volunteers from experiencing what we’ve suffered.”

“But there were other side effects,” Kim said.

“True,” Edward admitted. “I should have picked up on the short-term-memory loss as being significant. The drug was obviously showing its capability to block network-level nerve function.”

“Has your subsequent research led to any understanding of your condition?” Kim asked.

“By studying each other in the throes of an attack we’ve been able to document what we had originally proposed as the mechanism of action,” Gloria said. “Ultra builds up to a point where it blocks cerebral control of the limbic system and lower brain centers.”

“But why are you getting attacks now that the drug is gone?” Kim asked.

“That’s the question!” Edward said. “That’s what we are trying to learn. We believe it is through the same mechanism as ‘bad trip’ flashbacks which some people suffer after hallucinogenic drug use. We’re trying to investigate the problem so that we might be able to figure out a way to reverse it.”

“Dilantin worked for a short time to control the fits,” Gloria said. “But then we began to become tolerant, so now it no longer works. The fact that it influenced the process for a short term has us encouraged we might find another agent.”

“I’m surprised Omni is still in business,” Kim said to change the subject.

“We are too,” Edward said. “Surprised and pleased. Otherwise we wouldn’t have this lab. Stanton just has not given up, and his persistence has paid off. One of the other alkaloids from the new fungus has shown significant promise as a new antidepressant, so he’s been able to raise adequate capital.”

“I hope at least Omni has abandoned Ultra,” Kim said.

“No, indeed!” Edward said. “That’s the other major thrust of our research: trying to determine what part of the Ultra molecule is responsible for the meso-limbic-cerebral blockage that we’ve labeled ‘the Mr. Hyde Effect.’~”

“I see,” Kim said. She started to wish them luck but couldn’t get herself to do it. Not after all the trouble Ultra had already caused.

Kim was about to say goodbye and promise she’d be back to visit when she noticed Edward’s eyes glaze over. Then his entire face was transformed just as it had been on the fateful night when she’d awakened him. In an instant he was in an uncontrollable rage.

Without any warning or provocation he launched himself at Kim and collided with a thump against the thick glass shield.

Kim leaped back in fright. Gloria responded by swiftly opening Edward’s IV.

For a brief moment Edward clawed vainly at the glass. Then his face went slack and his eyes rolled up into his head. In slow motion he sagged like a balloon with its air slowly let out. Gloria skillfully guided him to the floor.

“I’m sorry about this,” Gloria said as she tenderly adjusted Edward’s head. “I hope Edward didn’t frighten you too much.”

“I’m fine,” Kim managed, but her heart was pounding in her chest and she was trembling. Warily she stepped close to the window and looked down at Edward lying on the floor. “Will he be all right?”

“Don’t worry,” Gloria said. “We’re rather used to this sort of thing. Now you can see why we have these IVs. We’ve been experimenting with various tranquilizers. I’m pleased with how quickly this one worked.”

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